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Objective To investigate the incidence of hypertension among Chinese middle-aged and elderly people, and to explore the association of sleep duration and sleep quality with the incidence of hypertension. Methods Our data were collected from the 2011 and 2015 China health and retirement longitudinal study(CHARLS),a total of 6 047 middle-aged and elderly individuals aged 45 years and over were included in this study, sleep duration were measured as self-reported average sleep time in the past month. Sleep quality was evaluated using the self-made questionnaire. The association of sleep duration and sleep quality with the incidence of hypertension was analyzed using multivariate logistic regression analysis. Results After four years of follow-up,1 151 peoples developed hypertension, and the cumulative incidence rate was 19.03%. Logistic regression analysis showed that abnormal sleep time or poor sleep quality had no effect on the incidence of hypertension. The results remained unchanged in the subgroup analysis of sex and age. Further investigation of the association of different combinations of sleep duration and quality in relation to hypertension indicated that the combined effect of sleep time and sleep quality on hypertension was not statistically significant (all P>0.05). Conclusion There is no sufficient evidence supporting correlation between sleep time and sleep quality with the incidence of hypertension in the middle-aged and the elderly in China, and age and sex had no effect on the correlation.
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OBJECTIVE: To investigate the pregnancy outcome and pregnancy complications in patients with subclinical hypothyroidism with negative anti-thyroid peroxidase(TPO-Ab)in early pregnancy.METHODS:From January 2016 to February 2018,4,616 cases of early-gestation pregnant women in Shanghai Tinglin Hospital were selected.According to the age,the patients were divided into groups of 18-24 years old(602 cases),25-29 years old(2604 cases),30-34 years old(1330 cases),and over 35 years old(80 cases).Subclinical incidence of TPO-Ab-negative hypothyroidism in pregnant women of different age groups was compared.According to whether TPO-Ab-negative subclinical hypothyroidism patients received LT4 replacement therapy, they were divided into treatment group(receiving treatment,160 cases)and observation group(not receiving treatment,98 cases),and 526 normal pregnant women in the same period were included as the control group.The incidence of various pregnancy complications and pregnancy outcomes and their statistical significance were compared among the three groups.RESULTS:Comparison of the incidence of TPO-Abnegative subclinical hypothyroidism:the age group of 30-34 years old(7.97%)was higher than the age group of 25-29 years old(5.99%)and the age group of 18-24 years old(3.99%);the age group of over 35 years old(12.50%)was higher than the age group of 25-29(5.99%)and the age group of 18-24(3.99%);the age of over 35 years old(12.50%)was higher than the age group of 25-29(5.99%)and the age group of 18-24(3.99%),and the differences were statistically significant(P<0.05).The incidence of gestational diabetes was higher in the observation group(14.29%)than in the treatment group(6.25%)and the control group(4.94%),and the incidence of anemia in the observation group(44.90%)was higher than that in the treatment group(30.00%)and the normal control group(26.04%).The neonatal birth weight of the treatment group(3200±300 g)and the control group(3150±statistical significance(P<0.05).CONCLUSION:The incidence of TPO-Ab-negative subclinical hypothyroidism in early pregnancy increases with age.Timely intervention should be given to reduce the occurrence of gestational anemia diabetes,which is conducive to the growth and development of offsprings.
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<p><b>OBJECTIVE</b>To differentiate patients with esophageal cancer or premalignant lesions from the high-risk population for preliminary screening of esophageal cancer using a feature index determined by a computer-aided tongue information acquisition and processing system (DS01-B).</p><p><b>METHODS</b>Totally, 213 patients diagnosed with esophageal cancer or premalignant lesions and 2,840 normal subjects were collected including primarily screened and reexamined, all of them were confirmed with histological examinations. Their tongue color space values and manifestation features were extracted by DS01-B and analyzed. Firstly, the analysis of variance was performed to differentiate normal subjects from patients with esophageal cancer and premalignant lesions. Secondly, the logistic regression was conducted using 10 features and gender, age to get a predictive equation of the possibility of esophageal cancer or premalignant lesions. Lastly, the equation was tested by subjects undergoing primary screening.</p><p><b>RESULTS</b>Saturation (S) values in the HSV color space showed significant differences between patients with esophageal cancer and normal subjects or those with mild atypical hyperplasia (P<0.05); blue-to-yellow (b) values in the Lab color space showed significant differences between patients with esophageal cancer or premalignant lesions and normal subjects (P<0.05). Logistic regression analysis showed that the computer-aided tongue inspection approach had an accuracy of 72.3% (2008/2776) in identifying patients with esophageal cancer or premalignant lesions for preliminary screening in high-risk population.</p><p><b>CONCLUSION</b>Computer-aided tongue inspection, with descriptive and quantitative profile as described in this study, could be applied as a cost- and timeefficient, non-invasive approach for preliminary screening of esophageal cancer in high-risk population.</p>
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<p><b>OBJECTIVE</b>To access the therapeutic effect of Tuina for treatment of infants eczema.</p><p><b>METHODS</b>Two hundred and forty children with eczema were randomly divided into a Tuina group and a medication group, 120 cases in each group. The Tuina group was treated with Tuina on ten points using the thumb and middle finger, and the medication group was treated with oral administration of Chlorpheniramine and topical application of zinc oxide ointment or Youzhuoer ointment, etc. The therapeutic effects were evaluated after 3 weeks.</p><p><b>RESULTS</b>The cured-markedly effective rate and total effective rate were 94.2% and 99.2% in the Tuina group and 98.0% and 100.0% in the medication group, respectively, the therapeutic effects were similar in the two groups (both P>0.05); 6 months after treatment, the recurrence rate of 3.8% in the Tuina group was significantly lower than 42.9% in the medication group (P<0.01), and there were no adverse reactions in the whole research process.</p><p><b>CONCLUSION</b>Tuina on ten points for treatment of infants eczema has unequivocal short-term effect, a stable long-term effect, and low recurrence rate.</p>
Subject(s)
Child, Preschool , Female , Humans , Infant , Male , Acupuncture Points , Administration, Oral , Administration, Topical , Chlorpheniramine , Dermatitis, Atopic , Drug Therapy , Therapeutics , Massage , Time Factors , Treatment Outcome , Zinc OxideABSTRACT
AIM: To assess the relative agreement of GAT and NCT in IOP measurement by comparing the differences between Goldmann applanation tonometer (GAT) and non-contact tonometer (NCT) in intraocular pressure (IOP) detection.METHODS: IOP of 529 eyes of 265 volunteers were measured with both NCT and GAT, respectively.RESULTS: The measurement results of NCT were lower than that of GAT, there was significant difference between the IOP measured with NCT and GAT (19.13 vs23.43, t=22.644, P＜0.05). With the increasing of IOP values, the difference magnitude was greater, especially in IOP group that was more than 30mmHg, but the correlation coefficient became lower.CONCLUSION: The measurement results with NCT are lower than that of GAT. When the IOP with the NCT is in borderline value, it need be corrected with GAT, in order to discover the pathologically elevated IOP and avoid the misdiagnosis and mistreatment of glaucoma.